PDGF is a multipotent cell growth factor, divided into three physiologically active forms AA/AB/BB, which are effective in promoting the growth of fibroblasts in both skin and soft tissue injury, with the BB form being more effective in promoting the growth of fibroblasts.
There are three aspects of the biological properties of PDGF:
1,Tropism, PDGF has tropism to fibroblasts, smooth muscle cells and neutrophils, PDGF induces tropism to fibroblasts and smooth muscle cells, which is very important in the process of injury repair.
2,The vasoconstriction effect of PDGF is stronger than that of angiotensin II in contracting rat aorta.
3,The pro-apoptotic effect of PDGF can stimulate the division and proliferation of various cells such as smooth muscle cells, fibroblasts and glial cells, and regulate the renewal of extracellular matrix by stimulating the synthesis of collagen and the activation of collagenase, ultimately promoting DNA synthesis and cell lysis and proliferation. In addition, PDGF binding to its receptor can affect the cytoskeleton and cell membrane in skeletal muscle and cause cytoskeletal rearrangement.